In the emrald suites there is this guy who is planning on breaking in to the gay man's vault. if you go in and kill/knock him out and you look underneath his pillow there is a toxic combat knife. it is awsome because if you get a hit on someone with it they are poisoned and cough and do not move. then you can just keep hacking until they die. that is a good stealth weapon. i also use the bowcaster.
I dont really know about biomods. what i ws using was the regenerate health, neural interface, lightfoot, strength, emp discharge, and i think that is it. i cant remember.

For some reason, I love the bot that flies around delivering nice poison-filled darts to people. It's very handy, IMHO.

I didn't know such an item exists I just gotta check it out for myself.

I'll have to get that knife. Dead sexy poison.

For Biomods I usually have Bot Hacking, Neural Interface, Silent Run, Regen helath, and thermal masking.

I use all the biomods in different saves, but my favorites are neural int., strength, quiet, thermal maksing, and regen. My current character has all of the drones, and it's a nice set up. My favorite weapons are a silenced pistol and an emp SMG. Pretty much all of them, actually. I'm quite versatile. =)

my favorite weapon has to be the smg. when i got it i upgraded it to have increased damage and frag. rounds it is very deadly. and when i use it on an opponent it looks very cool when the round explode on the person your using it on.

biomods
spy drone, at level three it will knock out humans and bots
bio masking
thermal masking, the dual makes for complete stealth
strenght, so I can carry more stuff and for my baton
the the quiet feet one, alto stealth

I love puting on bio stealth, going up to a persons face without them noticing me and then one shot with the baton to knock them out.....awesome
I wish you could upgrade melee weapons

upgrades
sniper: ammo-scav, and silencer
rocket: ammo-scav, and range (never realized how awesome secondary fire for the rocket is)
shotgun: increase damage, and ammo-scav (I love ammo-scav)

Dragons tooth sword and baton + strength = people killer (you'll need a gun for the armored templars tho)

Mag rail + vision enhancment = Electric things killer

Those and a sniper rifle, neural interface and health leech drone are the only things i really used during the game. tho the hellfire bolcaster is great fun too

as for biomods, i have no opinion except that regeneration sounds a lot more useful than it is, and same goes for cloak and thermal maksing and the power that make a little robot thing ah what the hell everything sucks except for what i said above, plus maybe bot dimination

also, does anyone know where i can find the "widowmaker smg?" i overheard some miedina citizens say something about it and i wonder if anyone could tell me if it is acutuall in the game

i think i found the widowmaker once, i don't remember where or how, but i DO remember it was largely the original, just with widowmaker stamped on the name. -shrug- either way, i go with a complete stealth/slicer setup. (can't really remember the mods or where they go.. been years since i last touched this game) but anything that really consider's stealth, and bot dom. i loved taking over those dog bots on that helipad, and walking right up to one of the guards, and shooting them right in the crotch and watching them fly..... try it sometime.. it's hilarious... and being able to unlock doors, and disable cams without wasting ammo or multi-tools makes for a nice resourceful touch, for everyone who... complains about not having enough ammo. -cough cough- and you wonder why i depend on stealth... so i don't NEED ammo.